I have an MSB Premier DAC and Digital Director, which is connected to a D’Agostino Momentum C2 preamp and Momentum S250 Amp. Does this added information change the recommendation?
Thanks for the update @dbelam . It does. With the director, you have great isolation and reclocking arriving before the DAC already. So the Pro USB vs USB vs Universal I2S are much closer to each other. The Pro USB as extra isolation, but I have this unnecessary with the Digital Director installed. I would probably encourage the standard USB input as it will give you the most flexibility for future system changes.
If you have a dealer who can give you an AB demo to choose between the USB and universal I2S, that could be the best way to make a final decision.
Just a FYI, the Universal I2S is not a clock synchronous input. I’ve yet to see a source with an I2S output that supports an external word-sync clock.
As Daniel said, both the USB sources will be clock synchronous as both are running off the audio clock in the DAC.